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Mislav Herman, Marina Ivanišević

Department of Obstetrics and Gynecology Hospital Medical Center Zagreb,
School of Medicine University of Zagreb

Key words: twin pregnancy, spontaneous preterm delivery, monochorionis twins, dichorionic twins, TTTS,
TRAP, selective fetal growth restriction

SUMMARY. Twin pregnancy is associated with higher rates of almost every potential complication of pregnancy. The
exceptions are postterm pregnancy and macrosomia. The most serious risk is spontaneous preterm delivery, which plays
a major role in the increased perinatal mortality and short-term and long-term morbidity observed in these infants.
Higher rates of fetal growth restriction and congenital anomalies also contribute to adverse outcome in twin births. In
addition, monochorionic twins are at risk for complications unique to these pregnancies, such as twin-twin transfusion
syndrome (TTTS), twin anemia-polycythemia sequence (TAPS), twin reversed arterial perfusion sequence (TRAP) and
selective fetal growth restriction which can be lethal or associated with serious morbidity.